Mycophenolate Mofetil Overdose Induced Ventricular Tachycardia in a Patient with Systemic Lupus Erythematosus
10.3904/kjm.2019.94.5.455
- Author:
Jung Hun KIM
1
;
Hyunji CHUNG
;
Kyung Ann LEE
;
Hae Rim KIM
;
Sang Heon LEE
Author Information
1. Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Mycophenolic acid;
Tachycardia, Ventricular;
Lupus erythematosus, Systemic
- MeSH:
Arrhythmias, Cardiac;
Cardiotoxicity;
Cholestyramine Resin;
Echocardiography;
Electrocardiography;
Female;
Heart Diseases;
Humans;
Lupus Erythematosus, Systemic;
Lupus Nephritis;
Mycophenolic Acid;
Potassium;
Tachycardia, Ventricular;
Young Adult
- From:Korean Journal of Medicine
2019;94(5):455-458
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mycophenolate mofetil (MMF) is an immunosuppressive agent used to treat severe lupus, including lupus nephritis. Common adverse effects of MMF include gastrointestinal and hematological manifestations; however, cardiac toxicity in association with MMF has not been reported. We present a 21-year-old woman with lupus nephritis who developed ventricular tachycardia 2 hours after an overdose of MMF (34 g). Ventricular bigeminy was documented 12 hours after the MMF overdose. Transthoracic echocardiography showed no evidence of structural heart disease. The ventricular arrhythmia was successfully treated with potassium replacement, hydration, and cholestyramine. This case suggests that an overdose of MMF can induce ventricular tachycardia, and electrocardiogram monitoring is critical to identify this rare cardiac complication of MMF.
