Vascular Calcification in Patients with Chronic Kidney Disease
10.3904/kjm.2019.94.2.159
- Author:
Ji Yong JUNG
1
Author Information
1. Division of Nephrology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. jyjung@gachon.ac.kr
- Publication Type:Review
- Keywords:
Vascular calcification;
Chronic kidney disease;
Vascular smooth muscle;
Trans-differentiation;
Mineralization
- MeSH:
Humans;
Metabolism;
Miners;
Mortality;
Muscle, Smooth, Vascular;
Osteoblasts;
Osteogenesis;
Renal Insufficiency, Chronic;
Vascular Calcification
- From:Korean Journal of Medicine
2019;94(2):159-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cardiovascular morbidity and mortality are very common in patients with chronic kidney disease, which may result in part from vascular calcification. Vascular calcification requires osteoblastic trans-differentiation of vascular smooth muscle cells through an active and highly regulated process that is morphologically and functionally similar to bone formation in a number of ways. Multiple studies have been published on this topic, but the precise mechanism of vascular calcification remains unclear. This review presents recent insights into the mechanism of vascular calcification, as well as therapies that modulate mineral metabolism.
