Two Cases of Opioid-Induced Hyperalgesia in Cancer Patients Treated with Opioids for Pain Management
- Author:
Sukchul HONG
1
;
Jung Hye KWON
;
Su Jung HAN
Author Information
1. Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea. kwonjhye.onco@gmail.com
- Publication Type:Case Report
- Keywords:
Neoplasms;
Pain;
Opioid analgesics;
Hyperalgesia
- MeSH:
Analgesics, Opioid;
Cognition Disorders;
Delirium;
Hallucinations;
Humans;
Hyperalgesia;
Myoclonus;
N-Methylaspartate;
Pain Management;
Respiratory Insufficiency;
Seizures;
Sleep Stages
- From:Korean Journal of Hospice and Palliative Care
2019;22(2):100-104
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Opioids are important drugs for the management of severe cancer pain without a ceiling effect. However, opioid administration leads to dose-limiting complications including drowsiness, hallucinations, delirium, respiratory depression, cognitive impairment, seizure, myoclonus, and hyperalgesia. Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon as opioid exposure increases pain sensitivity. Reducing or stopping opioids, opioid rotation, or co-administration of N-methyl-D-aspartate (NMDA) antagonists have been suggested for the management of OIH. In this study, we report two clinical cases of successful management of OIH in cancer pain patients that were treated with opioids.
