Mammary Paget's Disease of the Nipple: Relatively Common but Still Unknown to Many

Author: Poh Siang OOI ¹ ; Nani DRAMAN ; Siti Suhaila Mohd YUSOFF ; Wan Zainira Wan ZAIN ; Dharmendra GANASAGARAN ; Hui Heng CHUA
Author Information

1. Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Malaysia. drnani@usm.my
Publication Type:Case Report
Keywords: Breast Neoplasms; Eczema; Mammary Paget's Disease; Nipples
MeSH: Adenocarcinoma; Breast; Breast Neoplasms; Carcinogenesis; Eczema; Epidermis; Female; Humans; Inflammation; Malaysia; Middle Aged; Nipples; Paget's Disease, Mammary; Skin
From:Korean Journal of Family Medicine 2019;40(4):269-272
CountryRepublic of Korea
Language:English
Abstract: Mammary Paget's disease is clinically defined as skin inflammation of the nipple area and is an adenocarcinoma of the epidermis of the nipple. The pathogenesis of mammary Paget's disease is relatively unknown; nonetheless, there are two popular theories that support the underlying carcinoma and de novo carcinogenesis. For the attending medical practitioner, mammary Paget's disease poses a diagnostic and therapeutic dilemma, especially in the absence of a clinically palpable breast mass. We report a rare case of a 48-year-old Malay woman who presented at Hospital Universiti Sains Malaysia, Kelantan, Malaysia with the symptom of skin erosion on the left nipple and unresponsiveness to multiple topical treatments. A full evaluation and assessment of the patient were conducted, and mammary Paget's disease was diagnosed.