Cutaneous Angiosarcoma of the Foot Accompanied by Multiple Myeloma: The First Case Report
- Author:
Jeong Won JO
1
;
Young Bin SHIN
;
Chang Il KWON
;
Chi Yeon KIM
Author Information
1. Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, Korea. cykim@gnu.ac.kr
- Publication Type:Case Report
- Keywords:
Cutaneous angiosarcoma;
Foot;
Multiple myelomav;
MYC
- MeSH:
Diagnosis;
Foot;
Genes, myc;
Hemangiosarcoma;
Humans;
MicroRNAs;
Mortality;
Multiple Myeloma;
Neoplasm Metastasis;
Phenotype;
Proto-Oncogenes;
Recurrence;
Up-Regulation
- From:Korean Journal of Dermatology
2019;57(7):399-402
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although the exact etiology of cutaneous angiosarcoma remains unclear, MYC gene amplification has been recently discovered as a new pathogenesis. MYC is a proto-oncogene, and aberration of MYC signaling in malignancies is associated with tumor metastasis, recurrence, and mortality. Moreover, upregulation of the miRNA polycistron, miR-17-92 cluster, were confirmed in both cutaneous angiosarcoma and multiple myeloma with MYC amplification. The correlation between MYC and miRNA expression is predictable as the coincident aberrant phenotype in two diseases. Moreover, the exploiting MYC dependency may be an attractive disease-specific strategy for the diagnosis and treatment of patients who are unaware of the causes of cutaneous angiosarcoma. Herein, a rare case of cutaneous angiosarcoma of the foot, which is also the first case of cutaneous angiosarcoma accompanied by multiple myeloma, has been described.
