Three Cases of Recurrent Cheilitis Granulomatosa Treated with Variable Combination Therapy
- Author:
Seung Pil HAM
1
;
Hee Jae PARK
;
Cheong Ha WOO
;
Mira CHOI
;
Hai Jin PARK
Author Information
1. Department of Dermatology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. stratum@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Cheilitis granulomatosa;
Melkersson-Rosenthal syndrome;
Orofacial granulomatosis
- MeSH:
Cheek;
Cheilitis;
Chin;
Facial Paralysis;
Giant Cells;
Granuloma;
Granulomatosis, Orofacial;
Lip;
Melkersson-Rosenthal Syndrome;
Mouth Mucosa;
Rare Diseases;
Steroids;
Tongue, Fissured;
Triamcinolone
- From:Korean Journal of Dermatology
2019;57(4):209-212
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cheilitis granulomatosa (CG) is a subset of orofacial granulomatosis (OFG) and considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome (MRS), which is characterized by the triad of chronic lip swelling, facial paralysis, and fissured tongue. The labial swelling is thought to be associated with an orofacial swelling, which affects the chin, cheeks, and oral mucosa. Histologically, it is distinguished by noncaseating granulomas consisting of lymphohistiocytes and giant cells. Although systemic steroids with or without intralesional triamcinolone injections are the mainstay of treatment, and various agents have been proposed for this rare disease, no successful treatment modality has been reported in the literature yet. Herein, we present our experience with three different CG cases, which showed a varied level of positive response to the combination therapy.
