Psychiatric Symptoms after Taking Oseltamivir in a Child and Its Causality Assessment
10.24304/kjcp.2019.29.1.56
- Author:
Pyoungwoo SON
1
;
Joonghyuk CHOI
;
Seungmin LEE
;
Seon Soon PARK
;
Eunkyung CHOI
;
Bong Kyu YOO
;
Eunhee JI
Author Information
1. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea. ehji@gachon.ac.kr byoo@gachon.ac.kr
- Publication Type:Case Report
- Keywords:
Oseltamivir;
adverse event;
psychiatric symptom;
causality assessment;
community pharmacy
- MeSH:
Body Temperature;
Child;
Drug-Related Side Effects and Adverse Reactions;
Fever;
Global Health;
Humans;
Infant;
Influenza, Human;
Korea;
Male;
Oseltamivir;
Pharmacies
- From:Korean Journal of Clinical Pharmacy
2019;29(1):56-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Oseltamivir is an antiviral medication prescribed to prevent and treat influenza A and B. A case from a community pharmacy in Korea was reported for an adverse event associated with oseltamivir administration. A 20-month-old boy had psychiatric symptoms after receiving 2 doses of oseltamivir. Therefore, an evaluation of whether the psychiatric symptoms were caused by oseltamivir was required. To determine whether the adverse event resulted from the administrated medication or other factors, three tools were used: the Naranjo scale, the Korean causality assessment algorithm (Ver.2), and the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria. The psychiatric symptoms occurred after oseltamivir administration, and were attenuated after oseltamivir termination. A possible cause of the psychiatric symptoms is high fever, but information on the body temperature of the patient was not sufficient. Therefore, it was unclear whether there were other nonpharmacological causes of adverse drug reaction. For these reasons, in terms of causality, the results evaluated by the three tools represented, “possible”, “probable”, and “probable/likely”, respectively.
