Weak D type 33 Found in a Patient with a Weak D Phenotype: The First Case in Korea
10.17945/kjbt.2019.30.1.65
- Author:
HongBi YU
1
;
Jong Eun PARK
;
Geon PARK
;
Duck CHO
Author Information
1. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea. duck.cho@skku.edu
- Publication Type:Case Report
- Keywords:
RhD;
Weak D;
Phenotype;
Genotyping
- MeSH:
Asia;
Computer Simulation;
Exons;
Female;
Humans;
Korea;
Middle Aged;
Phenotype;
Serologic Tests
- From:Korean Journal of Blood Transfusion
2019;30(1):65-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
RHD genotyping is a useful adjunct to serologic testing. Although the use of RHD genotyping in the detection of Asia type DEL in serological D negative Koreans is gradually increasing, it is rarely requested for patients with a known weak D phenotype. This paper reports the first Korean case of a 52-year-old female patient with serologic weak D phenotype and weak D type 33 (c.520G>A at exon 4 of RHD) identified by RHD exon 1 to 10 sequencing. In silico analysis predicted that the RHD c.520G>A (V174M) results in a serologic weak D phenotype.
