Anaphylactic shock after sugammadex administration, induced by formation of a sugammadex-rocuronium complex: a case report
- Author:
Gunn Hee KIM
1
;
Won Seop CHOI
;
Ji Eun KIM
;
Mi Jung YUN
;
Min Seok KOO
;
Miyoung KWON
;
Hyungseok SEO
Author Information
- Publication Type:Case Report
- Keywords: Anaphylactic shock; Cyclodextrin; Epinephrine; Hypersensitivity; Rocuronium; Sugammadex
- MeSH: Adult; Anaphylaxis; Epinephrine; Health Personnel; Humans; Hypersensitivity; Neuromuscular Blockade; Neuromuscular Blocking Agents; Skin Tests
- From:Korean Journal of Anesthesiology 2019;72(5):495-499
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Sugammadex is a reversal agent for non-depolarizing neuromuscular blockers and widely used worldwide on account of its rapid and effective reversal from neuromuscular blockade, despite its advantages, multiple cases of sugammadex-induced anaphylactic shock have been reported. CASE: A 42-year-old man developed anaphylactic shock in the postanesthesia care unit. Initially, sugammadex was suspected as the causative agent, but an intradermal skin test revealed negative results. A further skin test was performed with sugammadex-rocuronium complex that yielded positive results. CONCLUSIONS: Anesthesiologists and healthcare providers should be aware of the possibility of anaphylaxis from the sugammadex-rocuronium complex, as well as from sugammadex or rocuronium alone.
