Randomization in clinical studies
- Author:
Chi Yeon LIM
1
;
Junyong IN
Author Information
- Publication Type:Randomized Controlled Trial
- Keywords: Adaptive randomization; Minimization; Random allocation; Randomization; Randomized controlled trial; Restrictive randomization; Simple randomization; Stratified randomization
- MeSH: Bias (Epidemiology); Ethics; Probability Theory; Random Allocation; Selection Bias
- From:Korean Journal of Anesthesiology 2019;72(3):221-232
- CountryRepublic of Korea
- Language:English
- Abstract: Randomized controlled trial is widely accepted as the best design for evaluating the efficacy of a new treatment because of the advantages of randomization (random allocation). Randomization eliminates accidental bias, including selection bias, and provides a base for allowing the use of probability theory. Despite its importance, randomization has not been properly understood. This article introduces the different randomization methods with examples: simple randomization; block randomization; adaptive randomization, including minimization; and response-adaptive randomization. Ethics related to randomization are also discussed. The study is helpful in understanding the basic concepts of randomization and how to use R software.
