Clinical Significance of Platelet Counts in Patients with Hepatocellular Carcinomas.
- Author:
Jin RYOO
1
;
Seong Woo HONG
;
Tae Gil HEO
;
Yeo Goo CHANG
;
Je Hoon PARK
;
Hyucksang LEE
Author Information
1. Department of Surgery, Seoul Paik Hospital, Inje University, Seoul, Korea. lib0196@thrunet.com
- Publication Type:Original Article
- Keywords:
Carcinoma, Hepatocellular;
Thrombocytosis;
Blood platelets
- MeSH:
Blood Platelets*;
Carcinoma, Hepatocellular*;
Colon;
Humans;
Incidence;
Lung;
Pancreatic Neoplasms;
Platelet Count*;
Portal Vein;
Retrospective Studies;
Stomach;
Thrombocytosis
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2005;9(3):145-149
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Thrombocytosis is reported in patients with various tumors, including stomach, colon, ovarian, lung and pancreatic cancers. Some clinical reports have shown thrombocytosis to be a poor prognostic factor in cancer patients. However, in hepatocellular carcinoma patients, the incidence and clinical significance of thrombocytosis have not been clearly verified. In this study, the clinical significance of platelet counts was investigated in patients with hepatocellular carcinomas. METHODS: 212 patients with surgically proven hepatocellular carcinomas were enrolled in this study. The incidence, relationship with other clinicopathological factors, and the prognostic value of thrombocytosis were retrospectively evaluated. RESULTS: The incidence of thrombocytosis (> or =400, 000/ul) was 2.8% (6/212). The platelet counts were elevated in patients with a large sized tumor (p< 0.001), advanced TNM stage (p=0.009) and gross tumor thrombi in the portal vein (p=0.009). There was no difference in the survival between patients with low and high platelet counts. CONCLUSION: The incidence of thrombocytosis in hepatocellular carcinoma patients was very low. The platelet counts were elevated in patients with advanced hepatocellular carcinomas, but no prognostic significance was shown in this study.
