Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents
- Author:
Wanhe LUO
1
;
Dongmei CHEN
;
Mengru WU
;
Zhenxia LI
;
Yanfei TAO
;
Qianying LIU
;
Yuanhu PAN
;
Wei QU
;
Zonghui YUAN
;
Shuyu XIE
Author Information
- Publication Type:Review
- Keywords: PK/PD models; dosage regimens; drug residues; bacterial infections; antimicrobial agents
- MeSH: Anti-Infective Agents; Bacterial Infections; Drug Residues; Humans; Treatment Failure; Veterinarians
- From:Journal of Veterinary Science 2019;20(5):e40-
- CountryRepublic of Korea
- Language:English
- Abstract: Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance. This review introduces building methods for PK/PD models and describes current PK/PD research progress toward rational dosage regimens for veterinary antimicrobial agents. Finally, the challenges and prospects of PK/PD models in the design of dosage regimens for veterinary antimicrobial agents are reviewed. This review will help to increase awareness of PK/PD modeling among veterinarians and hopefully promote its development and future use.
