Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
- Author:
Ren SAN
1
;
Weidong YUE
;
Surong HASI
Author Information
- Publication Type:Brief Communication
- Keywords: Bactrian camel; CYP1A; substrate; pharmacokinetics; inhibitor
- MeSH: Camels; Chromatography, Liquid; Half-Life; Pharmacokinetics; Plasma
- From:Journal of Veterinary Science 2019;20(3):e12-
- CountryRepublic of Korea
- Language:English
- Abstract: The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen only or with the enzyme inhibitor lomefloxacin. Blood samples were collected after different intervals, and p-acetaminophen concentration was determined by high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by Phoenix WinNonLin v.7.0. The results show that lomefloxacin can significantly inhibit Bactrian camel CYP1A enzyme, as evidenced by the prolonged elimination half-life, increased maximum plasma concentration and area under the curve values and the shortened time to peak concentration for p-acetaminophenol in the substrate with inhibitor group. The results lay a foundation for revealing the particular characteristics of the CYP1A enzyme in Bactrian camels.
