Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences
- Author:
Jin Il KIM
1
;
Sehee PARK
;
Joon Yong BAE
;
Man Seong PARK
Author Information
- Publication Type:Brief Communication
- Keywords: Middle East respiratory syndrome coronavirus; molecular evolution; phylogeny; zoonoses
- MeSH: Camels; Clinical Coding; Coronavirus Infections; Evolution, Molecular; Humans; Immunity, Innate; Middle East Respiratory Syndrome Coronavirus; Middle East; Open Reading Frames; Phylogeny; Zoonoses
- From:Journal of Veterinary Science 2019;20(2):e1-
- CountryRepublic of Korea
- Language:English
- Abstract: The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.
