Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum
10.4142/jvs.2018.19.3.472
- Author:
Francesca PERONDI
1
;
Claudio BROVIDA
;
Gianila CECCHERINI
;
Grazia GUIDI
;
Ilaria LIPPI
Author Information
1. Department of Veterinary Sciences, University of Pisa, 56122 Pisa, Italy. f.perondi87@gmail.com
- Publication Type:Case Report
- Keywords:
Leishmania infantum;
dogs;
double filtration plasmapheresis;
hyperproteinemia
- MeSH:
Animals;
Dogs;
Filtration;
gamma-Globulins;
Leishmania infantum;
Leishmania;
Plasmapheresis;
Renal Dialysis
- From:Journal of Veterinary Science
2018;19(3):472-476
- CountryRepublic of Korea
- Language:English
-
Abstract:
Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p < 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.
