Comparative aspects of microRNA expression in canine and human cancers
10.4142/jvs.2018.19.2.162
- Author:
Kabiru SAHABI
1
;
Gayathri T SELVARAJAH
;
Rasedee ABDULLAH
;
Yoke Kqueen CHEAH
;
Geok Chin TAN
Author Information
1. Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Malaysia. gayathri@upm.edu.my
- Publication Type:Review
- Keywords:
dogs;
gene expression;
microRNAs;
neoplasms;
stem cells
- MeSH:
Animals;
Biology;
Carcinogenesis;
Dogs;
Gene Expression;
Humans;
Invertebrates;
MicroRNAs;
Neoplastic Stem Cells;
Stem Cells;
Vertebrates
- From:Journal of Veterinary Science
2018;19(2):162-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed.
