Tibial dyschondroplasia is closely related to suppression of expression of hypoxia-inducible factors 1α, 2α, and 3α in chickens
10.4142/jvs.2018.19.1.107
- Author:
Shucheng HUANG
1
;
Mujeeb U REHMAN
;
Gang QIU
;
Houqiang LUO
;
Muhammad K IQBAL
;
Hui ZHANG
;
Khalid MEHMOOD
;
Jiakui LI
Author Information
1. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China. lijk210@sina.com
- Publication Type:Original Article
- Keywords:
Tibetan chickens;
growth plate;
high altitude;
hypoxia-inducible factors-1α;
tibial dyschondroplasia
- MeSH:
Anoxia;
Blotting, Western;
Chickens;
Growth Plate;
Osteochondrodysplasias;
Poultry;
Reverse Transcriptase Polymerase Chain Reaction;
RNA;
Thiram
- From:Journal of Veterinary Science
2018;19(1):107-115
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tibial dyschondroplasia (TD) cases has not been reported in Tibetan chickens (TBCs), but it is commonly seen in commercial broilers characterized by lameness. The underlying mechanism remains unclear. Hypoxia-inducible factors (HIFs) are important regulators of cellular adaptation to hypoxic conditions. In this study, we investigated the role of HIF-1α,
