Evaluation of a fixed-dose combination of benazepril and pimobendan in dogs with congestive heart failure: a randomized non-inferiority clinical trial
10.4142/jvs.2018.19.1.117
- Author:
Jonathan N KING
1
;
Atsushi HIRAKAWA
;
Junko SONOBE
;
Hiroshi OTAKI
;
Nobuhiro SAKAKIBARA
;
Wolfgang SEEWALD
;
Sophie FORSTER
Author Information
1. Elanco Animal Health, Basel CH-4002, Switzerland. jonathan.king@elanco.com
- Publication Type:Clinical Trial
- Keywords:
benazepril;
congestive heart failure;
dogs;
pimobendan
- MeSH:
Animals;
Chemistry, Clinical;
Diuretics;
Dogs;
Estrogens, Conjugated (USP);
Heart Failure;
Hematology;
Japan;
Masks;
Mitral Valve;
Vomiting
- From:Journal of Veterinary Science
2018;19(1):117-128
- CountryRepublic of Korea
- Language:English
-
Abstract:
A fixed-dose combination tablet of benazepril and pimobendan (Fortekor Plus; Elanco Animal Health) was tested in dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD) in a three-arm, masked, randomized, non-inferiority clinical trial in Japan. The test group (n = 34) received Fortekor Plus twice daily. Two control groups received registered formulations of benazepril (Fortekor; Elanco Animal Health) and pimobendan (Vetmedin; Boehringer Ingelheim Vetmedica) with administration of Vetmedin twice daily and Fortekor twice (Control I, n = 14) or once (Control II, n = 19) daily. Diuretics were used in 22 dogs (32.8%). Global clinical scores decreased significantly from baseline in all groups; there were no significant differences between groups, and non-inferiority of Fortekor Plus compared to Control I, Control II, and combined Control I + II groups was demonstrated. There were no significant differences between groups for relevant clinical chemistry and hematology variables or frequency of all adverse events. Frequency of emesis was significantly (p = 0.0042) lower in the Fortekor Plus (8.8%) group than in the Control I + II (39.4%) group. In conclusion, Fortekor Plus had non-inferior efficacy and was associated with significantly less emesis compared to Fortekor and Vetmedin in dogs with CHF caused by MMVD.
