Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model
10.4142/jvs.2018.19.1.137
- Author:
Sooyoung CHOI
1
;
Daji NOH
;
Youngwhan KIM
;
Inseong JEONG
;
Hojung CHOI
;
Youngwon LEE
;
Kija LEE
Author Information
1. Ian Animal Diagnostic Center, Seoul 06014, Korea.
- Publication Type:Original Article
- Keywords:
brain infarction;
dogs;
lateral ventricles;
magnetic resonance imaging;
time passage
- MeSH:
Animals;
Brain Infarction;
Brain;
Diffusion;
Dogs;
Lateral Ventricles;
Magnetic Resonance Imaging;
Necrosis;
Neurons;
Stroke
- From:Journal of Veterinary Science
2018;19(1):137-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study describes magnetic resonance imaging (MRI) results and changes in lateral ventricular size over time in a canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence MRI were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping were performed at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs. At 3 h, T2W and FLAIR detected hyperintense lesions in three randomly selected dogs. On T1W, all lesions appeared hypointense to isointense at 3 h, isointense (18/29) or hypointense (11/29) at 3 days, hypointense to isointense with peripheral hyperintensity (24/26) at 8 days, and hypointense (18/26) at 35 days. Infarcts on DWI/ADC were hypointense to isointense centrally, with the periphery hyperintense/hyperintense (17/26) at 8 days and hypointense/hyperintense (19/26) at 35 days. A marked increase in lateral ventricular size was observed in dogs with cerebral infarcts. In conclusion, T2W and FLAIR were useful for detecting early stage (3 h to 3 days) brain infarction. T1W and DWI were useful for detecting neuronal necrosis and providing supplemental information for phase evaluation.
