Therapeutic Effects of Lipo-Prostaglandin E1 in Buerger's Disease
- Author:
Sae Guk KI
1
;
Young Wook KIM
Author Information
1. Department of Surgery, Kyungpook National University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Buerger's disease;
Prostaglandin E
- MeSH:
Alprostadil;
Ankle Brachial Index;
Humans;
Photoplethysmography;
Prospective Studies;
Thromboangiitis Obliterans;
Toes;
Ulcer
- From:Journal of the Korean Society for Vascular Surgery
1998;14(2):231-235
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To observe the therapeutic effects of iv Lipo-prostaglandin E1 for the patients with Buerger's disease, 16 patients presenting severe peripheral ischemic symptom were enrolled and prospectively assessed the efficacy of Lipo-PGE1 after 4 weeks of iv bolus injection of Lipo-PGE1. Pain relief, reduction of ulcer size, change of ankle brachial index and change of toe pressure measured with photoplethysmography were assessed as end points of therapeutic efficacy. After 4 weeks of treatment, 69.2% of patients revealed pain relief, 33.3% revealed reduction of ulcer size (>50%), 18.8% revealed increased ankle brachial index (>0.15), and 18.8% revealed increased toe pressure. The side effects of iv bolus Lipo-prostaglandin E therapy was minimal.
