The Effect of Nasal Steroid Spray on Contact Granuloma of Larynx
- Author:
GilJoon LEE
1
;
Dongbin AHN
;
Jin Ho SOHN
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Daegu, Korea. sohnjh@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Contact granuloma;
Larynx;
Nasal steroid spray
- MeSH:
Granuloma;
Granuloma, Laryngeal;
Humans;
Intubation;
Intubation, Intratracheal;
Larynx;
Methods;
Microsurgery;
Nasal Cavity;
Risk Factors;
Voice
- From:Journal of the Korean Society of Laryngology Phoniatrics and Logopedics
2018;29(2):79-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Laryngeal contact granuloma is benign inflammatory disease induced by excessive mechanical contact of larynx such as endotracheal intubation, voice abuse, laryngeal microsurgery as well as laryngopharygeal reflux. Because it is caused by various risk factors, multiple treatment modalities are required. The purpose of study is to evaluate treatment effect of topical steroid through nasal cavity in contact granuloma. MATERIALS AND METHOD: Fifty-two patients were enrolled in this study with exception of intubation granuloma. Patients were classified with four groups (Proton pump inhibitor (PPI), Nasal steroid spray (SPR), PPI+SPR, Observation) according to treatment modality. RESULTS: Patients who treated with PPI (Odds ratio 2.45, p=0.03) and combination of PPI and SPR (Odds ratio 2.88, p<0.01) had significantly better response than patients who not treated with medical therapy. CONCLUSION: Combination therapy of nasal steroid spray and PPI is effective for contact granuloma of larynx and considered as a treatment of choice rather than PPI only treatment.
