Multicenter Evaluation on the Efficacy of N-Acetyl Cystine in Relieving the Symptoms of Laryngopharyngeal Reflux Disease
- Author:
So Yean KIM
1
;
Tack Kyun KWON
;
Han Su KIM
;
Young Ik SON
;
Seung Hoon WOO
;
Jeong Soo WOO
;
Seung Won LEE
;
Jae Yol LIM
;
Man Ki CHUNG
;
Young Hoon JOO
;
Wonjae CHA
;
Seung Ho CHOI
;
Hyun Jun HONG
;
Sang Hyuk LEE
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. entlsh@hanmail.net
- Publication Type:Multicenter Study
- Keywords:
Laryngopharyngeal reflux;
N-acetyl cysteine;
Inhalation;
Treatmen;
Symptom
- MeSH:
Antioxidants;
Compliance;
Cysteine;
Cystine;
Humans;
Inhalation;
Laryngopharyngeal Reflux;
Medical Records;
Nausea;
Pharynx;
Retrospective Studies
- From:Journal of the Korean Society of Laryngology Phoniatrics and Logopedics
2018;29(2):87-93
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Laryngopharyngeal reflux disease (LPRD) is relatively common disease. N-acetyl cysteine (NAC) has both mucolytic and antioxidant effect, also may be beneficial in inflammatory airway diseases. The purpose of this study was to evaluate the efficacy and safety of inhaled NAC therapy in LPRD. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 525 LPRD patients at 12 medical centers. Finally 401 patients subjected to inhaled NAC therapy for 2 months were enrolled in the study. We analyzed the change of Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) after use of NAC for 4 weeks and 8 weeks in addition to the patient's compliance of the treatment. RESULTS: The RSI score significantly decreased from 19.87±6.34 to 12.78±6.93 after 4 weeks and to 10.65±7.47 after 8 weeks. The RFS score also significantly decreased from 9.29±3.4 to 7.17±3.41 after 4 weeks and to 6.1±3.73 after 8 weeks (p<0.05). During the treatment periods, 42 patients (10.4%) reported to have 80 episodes of discomfort. Throat discomfort (33%) and nausea (28%) were most common complaints, but the duration of discomfort was usually less than 4 weeks. CONCLUSION: Inhaled NAC treatment is highly effective for the reduction of both subjective and objective findings in LPRD patients. This study will provide the evidence of new treatment option for patients with LPRD. However, further studies will be needs to assess the real effect of inhaled NAC therapy as a standard treatment regimen of LPRD.
