A novel unidirectional porous β-tricalcium phosphate grafting for vertebral fracture in the elderly: preliminary case series

Toru Funayama; Toshinori Tsukanishi; Hiroshi Kumagai; Hiroshi Noguchi; Shigeo Izawa; Tetsuya Abe; Kousei Miura; Katsuya Nagashima; Kentaro Mataki; Yosuke Shibao; Kosuke Sato; Masao Koda; Masashi Yamazaki

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A novel unidirectional porous β-tricalcium phosphate grafting for vertebral fracture in the elderly: preliminary case series

VernacularTitle:A novel unidirectional porous β-tricalcium phosphate grafting for vertebral fracture in the elderly: preliminary case series
Author: Toru FUNAYAMA ¹ ; Toshinori TSUKANISHI ² ; Hiroshi KUMAGAI ¹ ; Hiroshi NOGUCHI ¹ ; Shigeo IZAWA ¹ ; Tetsuya ABE ¹ ; Kousei MIURA ¹ ; Katsuya NAGASHIMA ¹ ; Kentaro MATAKI ¹ ; Yosuke SHIBAO ¹ ; Kosuke SATO ¹ ; Masao KODA ¹ ; Masashi YAMAZAKI ¹
Author Information

1. Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Japan
2. Department of Orthopedic Surgery, Kenpoku Medical Center Takahagi Kyodo Hospital, Japan
Keywords: artificial bone; unidirectional porous β-tricalcium phosphate; vertebral fracture; elderly patients; osteoporosis
From:Journal of Rural Medicine 2019;14(2):211-215
CountryJapan
Language:English
Abstract: Objective: To treat vertebral fractures with posterior wall injury in the elderly, vertebral bone grafting is generally performed through a posterior transpedicular approach, combined with pedicle screw fixation. An autologous bone is ideal to treat this disorder. However, harvesting autologous bones from the elderly with osteoporosis is limited by the amount and quality of available autologous bone. Thus, we developed a bone-grafting substitute. The newly developed unidirectional porous β-tricalcium phosphate, with a porosity of 57% (UDPTCP; Affinos®, Kuraray Co., Ltd., Tokyo, Japan), is used in the bone-grafting procedure. This is the first report of UDPTCP used as an artificial bone graft in patients with an acute vertebral burst fracture.Materials and Methods: UDPTCP (mean: 4.2 g) was implanted through the pedicle, and posterior instrumentation was achieved with pedicle screws in five elderly patients. Resorption of UDPTCP and substitution with the autologous bone were evaluated on computed tomography (CT) and plain X-ray performed immediately and at 3, 6, and 12 months after the operation.Results: In case 1, the pedicle screws did not loosen, and UDPTCP was completely resorbed and replaced with the autologous bone at 3 postoperative months. In the other four cases, although the pedicle screws or the caudal part loosened because of osteoporosis, resorption of UDPTCP was observed at 3 postoperative months. At 6 postoperative months, progressive substitution with the autologous bone was confirmed, and at 12 postoperative months, formation of the good autologous bone was confirmed.Conclusion: This preliminary case series demonstrated that the newly developed UDPTCP shows good clinical potential as a bone-graft substitute for acute vertebral burst fractures in the elderly, including patients with osteoporosis.