A Cabe of Clozapine-Induced Agranulocytosis.
- Author:
Gi Chul LEE
1
;
Hong Kyung JUNG
;
Jung Ho LEE
;
Young Min CHOI
;
Seung Ill JEON
;
Soo Jeon CHOI
Author Information
1. Department of Neuropsychiatry, Sanggye Paik Hospital, Inje University Medical College, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Clozapine;
Agranulocytosis
- MeSH:
Agranulocytosis*;
Anti-Bacterial Agents;
Attention;
Clozapine;
Female;
Genes, Dominant;
Granulocyte-Macrophage Colony-Stimulating Factor;
Humans;
Major Histocompatibility Complex;
Risk Factors;
United Nations;
Young Adult
- From:Journal of Korean Neuropsychiatric Association
1998;37(1):186-193
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a 20-year-old female patient who developed clozapine-induced agranulocytosis on the 29th day of clozapine treatment. She recovered from the agranulocytosis on the 8th day of progression after treatment with G-CSE, GM-CSF, antibiotics and associated aseptic procedures. The cause of clozapine-induced agranulocytosis is still un known and it is proposed that the dominant gene of major histocompatibility complex region and the reactive metabolites which suppress the myeloid system may be responsible. We recommend that careful attentions such as the selection of patient, evaluation of the risk factors, and the thorough control of CPMS should be paid. If the agranulocytosis happens, it is helpful to consult to the department of medicine immediately.
