Characterization of the Body Constituent Patterns for Symptomatic Acute Cerebral Infarction Using qi-ketsu-sui Score

Yoshikazu Mizoi; Koichiro Tanaka; Shinichiro Ueda; Hideyuki Isobe; Kazuhiko Nara; Koki Chiba; Nobuo Araki; Toshimasa Yamamoto

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Characterization of the Body Constituent Patterns for Symptomatic Acute Cerebral Infarction Using qi-ketsu-sui Score

VernacularTitle:症候性の急性期脳梗塞患者を対象とした気血水スコアを用いた証の特徴
Author: Yoshikazu MIZOI ¹ ; Koichiro TANAKA ² ; Shinichiro UEDA ³ ; Hideyuki ISOBE ⁴ ; Kazuhiko NARA ² ; Koki CHIBA ² ; Nobuo ARAKI ¹ ; Toshimasa YAMAMOTO ¹
Author Information

1. Department of Neurology, Saitama Medical University, School of Medicine
2. Department of Traditional Medicine, Toho University Omori Medical Center, School of Medicine
3. Department of Clinical Research and Quality Management, University of The Ryukyus, Graduate School of Medicine
4. Department of Oriental Medicine, Saitama Medical University, School of Medicine
Keywords: symptomatic acute cerebral infarction; qi-ketsu-sui score; adjusted odds ratio; stratified analysis; blood stasis
From:Kampo Medicine 2018;69(4):321-327
CountryJapan
Language:Japanese
Abstract: We evaluated body constituent patterns of 130 consecutive patients with symptomatic acute cerebral infarction. They comprise lacunar infarction (n = 47), atherothrombotic infarction (n = 70), cardiogenic embolism (n = 11), and other type of infarction (n = 2). We compared body constituent patterns between them and 93 consecutive patients with other neurological diseases of the same age. We used qi-ketsu-sui scores to evaluate body constituent patterns in all cases. Qi-ketsu-sui scores measure six factors : qi deficiency (kikyo), qi stagnation (kiutsu), qi counterflow (kigyaku), blood deficiency (kekkyo), blood stasis (oketsu), and fluid retention (suitai). As a result of multivariate model analysis, symptomatic acute cerebral infarction had the largest weight of blood stasis and an adjusted odds ratio (95% confidence interval) was 4.6 (2.45-8.91). Even when gender as a confounding factor was adjusted by stratified analysis, adjusted odds ratios of blood stasis (95% confidence interval) were 7.46 (3.02-20.25) for males and 2.63 (1.02-7.11) for females, and those were maximum. The point (median, interquartile range) of blood stasis was more severe in acute cerebral infarction (24 points, 18-33 points) than other neurological diseases (16 points, 9-23 points). We examined relationships between body constituent patterns and clinical disease type, severity at hospitalization, and sex in patients with symptomatic acute cerebral infarction. Ratio of blood stasis was the largest in any clinical disease type, severity and sex. Blood stasis seemed to be the most important factor in symptomatic acute cerebral infarction.