Effects of Oral Rinse with Hangeshashinto Alone and Hangeshashinto with Honey for Oral Discomfort in Terminally-ill Cancer Patients

Satoshi Murakami; Asami Igarashi; Kanako Miyano; Yasuhito Uezono; Wakako Yatsuoka; Takao Ueno; Eri Suzuki; Taeko Ishii; Hiromi Matsuda

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Effects of Oral Rinse with Hangeshashinto Alone and Hangeshashinto with Honey for Oral Discomfort in Terminally-ill Cancer Patients

VernacularTitle:終末期がん患者の口腔内不快事象に対する蜂蜜併用半夏瀉心湯の含嗽による有効性の検討
Author: Satoshi MURAKAMI ¹ ; Asami IGARASHI ² ; Kanako MIYANO ³ ; Yasuhito UEZONO ³ ; Wakako YATSUOKA ⁴ ; Takao UENO ⁴ ; Eri SUZUKI ⁵ ; Taeko ISHII ⁶ ; Hiromi MATSUDA ⁶
Author Information

1. Department of Palliative Medicine, Seirei Sakura Citizen Hospital
2. Department of Rehabilitation, Seirei Sakura Citizen Hospital
3. Division of Cancer Pathophysiology, National Cancer Center Research Institute
4. Dental Division, National Cancer Center Hospital
5. Department of Nursing, Seirei Sakura Citizen Hospital
6. Department of Pharmacology, Seirei Sakura Citizen Hospital
Keywords: oral discomfort; oral mucositis; Hangeshashinto; rinse; honey
From:Palliative Care Research 2019;14(3):159-167
CountryJapan
Language:Japanese
Abstract: Purpose: The purpose of this study is to evaluate hangeshashinto rinse for oral discomfort in terminally-ill cancer patients and to compare the effectiveness of hangeshashinto rinse with or without honey rinse. Methods: Patients with oral discomfort were randomized to receive either hangeshashinto rinse or hangeshashinto with honey rinse as first-line treatment. Patients performed oral rinse three to five times a day for 2 weeks. Further, oral wetness, halitosis, oral mucositis, mouth discomfort, compliance of rinse were then evaluated before and after the intervention. Results: 144 patients were enrolled during this period and 22 patients completed the study (hangeshashinto 13 / hangeshashinto with honey 9). After the intervention, oral wetness was improved, and end-tidal concentration of hydrogen sulfide was decreased in both cases. Although there was no statistically significant difference, oral discomfort by subjective and objective evaluations, also and symptom of oral mucositis were improved. Other volatile sulfur compounds decreased. Frequency of rinsing between groups receiving hangeshashinto or hangeshashinto with honey did not differ, however, the acceptability was slightly better in the honey combination group. Conclusion: Both hangeshashinto rinse and hangeshashinto with honey rinse reduced end-tidal concentration of hydrogen sulfide and improved oral wetness. Oral rinse by hangeshashinto or hangeshashinto with honey may be effective for oral discomfort in terminally-ill cancer patients.