Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide of Different Volumes: Comparing 0.1 ml vs 0.05 ml.
10.3341/jkos.2008.49.4.589
- Author:
Sung Yong PARK
1
;
Kyung Seek CHOI
Author Information
1. Department of Ophthalmology, Soonchunhyang University, College of Medicine, Seoul, Korea. ckseek@naver.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Central macular thickness;
Intraocular pressure;
Intravitreal triamcinolone acetonide injection
- MeSH:
Follow-Up Studies;
Humans;
Intraocular Pressure;
Retrospective Studies;
Triamcinolone;
Triamcinolone Acetonide
- From:Journal of the Korean Ophthalmological Society
2008;49(4):589-594
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess whether a 4 mg/0.05 ml intravitreal triamcinolone acetonide injection can reduce the IOP elevation compared to conventional 4 mg/0.1 ml injection. METHODS: A retrospective case study was performed in 48 patients (48 eyes) who received intravitreal triamcinolone acetonide injection and who had a minimum follow-up time of six months. Patients were randomly assigned to receive 4 mg/0.1 ml or 4 mg/0.05 ml (24 patients in each group). RESULTS: Before injection, mean IOP was 13.8+/-2.2 mmHg and 13.9+/-2.4 mmHg in the 0.1 ml and 0.05 ml group. The difference in IOP elevation between the two groups was statistically significant immediately after injection (P=0.000), one hour after injection (P=0.001), and one day after injection (P=0.000). After injection, the central macular thickness decreased significantly the of two groups. The difference of the central macular thickness decrease between both groups was not statistically significant. CONCLUSIONS: An intravitreal triamcinolone acetonide 4 mg/0.05 ml injection will more quickly reduce the IOP elevation in the early phase compared to 4 mg/0.1 ml injection, while providing a similar effect on the change of central macular thickness.
