Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10.
- Author:
Qing Yin ZHENG
1
;
Belinda S HARRIS
;
Patricia F WARD-BAILEY
;
Heping YU
;
Roderick T BRONSON
;
Muriel T DAVISSON
;
Kenneth R JOHNSON
Author Information
1. The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
- Publication Type:Journal Article
- From:Academic Journal of Xi'an Jiaotong University
2004;25(3):209-212
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.
