The essential adaptors of innate immune signaling.
10.1007/s13238-012-2063-0
- Author:
Huihui CHEN
1
;
Zhengfan JIANG
Author Information
1. School of Life Sciences, Peking University, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Adaptive Immunity;
Adaptor Proteins, Signal Transducing;
immunology;
metabolism;
Animals;
Humans;
Immunity, Innate;
Signal Transduction;
immunology
- From:
Protein & Cell
2013;4(1):27-39
- CountryChina
- Language:English
-
Abstract:
Microbial components and the endogenous molecules released from damaged cells can stimulate germ-line-encoded pattern recognition receptors (PRRs) to transduce signals to the hub of the innate immune signaling network-the adaptor proteins MyD88/TRIF/MAVS/STING/Caspase-1, where integrated signals relay to the relevant transcription factors IRF3/IRF7/NF-κB/ AP-1 and the signal transducer and activator of transcription 6 (STAT6) to trigger the expression of type I interferons and inflammatory cytokines or the assembly of inflammasomes. Most pleiotropic cytokines are secreted and bind to specific receptors, activating the signaling pathways including JAK-STAT for the proliferation, differentiation and functional capacity of immune cells. This review focuses on several critical adaptors in innate immune signaling cascades and recent progress in their molecular mechanisms.
