New components of the necroptotic pathway.
10.1007/s13238-012-2083-9
- Author:
Zhenru ZHOU
1
;
Victor HAN
;
Jiahuai HAN
Author Information
1. State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Carrier Proteins;
metabolism;
DNA-Binding Proteins;
metabolism;
GTP Phosphohydrolases;
metabolism;
Humans;
Microtubule-Associated Proteins;
metabolism;
Mitochondrial Proteins;
metabolism;
Necrosis;
Phosphoprotein Phosphatases;
Protein Kinases;
chemistry;
metabolism;
Receptor-Interacting Protein Serine-Threonine Kinases;
metabolism;
Signal Transduction;
Tumor Necrosis Factors;
metabolism
- From:
Protein & Cell
2012;3(11):811-817
- CountryChina
- Language:English
-
Abstract:
Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
