MCP-1-induced protein-1, an immune regulator.
10.1007/s13238-012-2075-9
- Author:
Jiwei XU
1
;
Sheng FU
;
Wei PENG
;
Zihe RAO
Author Information
1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
Animals;
Humans;
Immunity;
Molecular Sequence Data;
Ribonucleases;
metabolism;
Transcription Factors;
chemistry;
metabolism;
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins;
metabolism;
Ubiquitination
- From:
Protein & Cell
2012;3(12):903-910
- CountryChina
- Language:English
-
Abstract:
MCP-1-induced protein-1 (MCPIP1) is a newly identified protein that is crucial to immune regulation. Mice lacking MCPIP1 gene suffer from severe immune disorders, and most of them cannot survive longer than 12 weeks. Considerable progress has been made in revealing the mechanism underlying the immune regulatory function of MCPIP1. MCPIP1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines, such as IL-6 and IL-1. Pre-microRNAs are also confirmed to be the substrate of MCPIP1 RNase. The structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure, further supporting the notion that MCPIP1 has RNase activity. MCPIP1 can also deubiquitinate TNF receptor-associated factor family proteins, which are known to mediate immune and inflammatory responses. In this review, we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function.
