A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins.
10.1007/s13238-012-2087-5
- Author:
Yuna SUN
1
;
Yu GUO
;
Zhiyong LOU
Author Information
1. National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Capsid;
metabolism;
Humans;
Lassa virus;
chemistry;
physiology;
Nucleocapsid Proteins;
chemistry;
metabolism;
Orthobunyavirus;
chemistry;
physiology;
RNA Viruses;
chemistry;
physiology
- From:
Protein & Cell
2012;3(12):893-902
- CountryChina
- Language:English
-
Abstract:
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
