Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism.
10.1007/s13238-012-2940-6
- Author:
Wensu LIU
1
;
Ming LI
;
Jing QU
;
Fei YI
;
Guang-Hui LIU
Author Information
1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
- Publication Type:News
- MeSH:
Cellular Reprogramming;
DNA Copy Number Variations;
Humans;
Induced Pluripotent Stem Cells;
metabolism;
Mosaicism;
Regenerative Medicine
- From:
Protein & Cell
2013;4(2):83-85
- CountryChina
- Language:English
-
Abstract:
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
