The sequence signature of an Ig-fold.
10.1007/s13238-013-3903-2
- Author:
Jia-Huai WANG
1
Author Information
1. Dana-Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA. jwang@red.dfci.harvard.edu
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
Humans;
Hydrogen Bonding;
Immunoglobulins;
chemistry;
metabolism;
Molecular Sequence Data;
Protein Folding;
Protein Structure, Tertiary
- From:
Protein & Cell
2013;4(8):569-572
- CountryChina
- Language:English
-
Abstract:
Ig superfamily (IgSF) constitutes the largest superfamily in human genome. In particular, Ig-like domains are the most abundant structural module within cell surface receptors, functioning in nervous as well as immune system. Here I describe some key sequence signature of an I-set Ig-like domain from known structures of IgSF members. These signature residues define the I-set Ig-like domain, which should aid structural and functional studies of cell surface receptors.
