siRNA-mediated DNA methylation and H3K9 dimethylation in plants.
10.1007/s13238-013-3052-7
- Author:
Chi XU
1
;
Jing TIAN
2
;
Beixin MO
3
Author Information
1. College of Life Science, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, 518060, China.
2. College of Life Science, Shenzhen Key Laboratory of Marine Biological Resources and Ecological Environment, Shenzhen University, Shenzhen, 518060, China.
3. College of Life Science, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, 518060, China. bmo@szu.edu.cn.
- Publication Type:Journal Article
- Keywords:
DNA methylation;
argonaute;
epigenetic;
heterochromatic siRNA;
histone methylation
- MeSH:
Arabidopsis;
genetics;
metabolism;
DNA Methylation;
Epigenesis, Genetic;
Gene Silencing;
Histones;
metabolism;
Methylation;
Plant Proteins;
metabolism;
Plants;
genetics;
metabolism;
RNA, Small Interfering;
biosynthesis;
genetics
- From:
Protein & Cell
2013;4(9):656-663
- CountryChina
- Language:English
-
Abstract:
Heterochromatic siRNAs regulate transcriptional gene silencing by inducing DNA methylation and histone H3K9 dimethylation. Recent advances have revealed the distinct phases involved in siRNA mediated silencing pathway, although the precise functions of a number of factors remain undesignated, putative mechanisms for the connection between DNA and histone methylation have been investigated, and much effort has been invested to understand the biological functions of siRNA-mediated epigenetic modification. In this review, we summarize the mechanism of siRNA-mediated epigenetic modification, which involves the production of siRNA and the recruitments of DNA and histone methytransferases to the target sequences assisted by complementary pairing between 24-nt siRNAs and nascent scaffold RNAs, the roles of siRNA-mediated epigenetic modification in maintaining genome stability and regulating gene expression have been discussed, newly identified players of the siRNA mediated silencing pathway have also been introduced.
