microRNAs: tiny RNA molecules, huge driving forces to move the cell.
10.1007/s13238-010-0116-9
- Author:
Shenglin HUANG
1
;
Xianghuo HE
Author Information
1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Movement;
genetics;
Gene Expression;
Gene Expression Regulation;
Humans;
MicroRNAs;
genetics;
metabolism;
physiology;
RNA;
genetics;
RNA, Untranslated;
genetics
- From:
Protein & Cell
2010;1(10):916-926
- CountryChina
- Language:English
-
Abstract:
Cell migration or movement is a highly dynamic cellular process, requiring precise regulation that is essential for a variety of biological processes. microRNAs (miRNAs) are a class of tiny non-coding RNA molecules that function as critical post-transcriptional regulators of gene expression. Emerging evidence demonstrates that miRNAs play important roles in cell migration and directly contribute to extracellular matrix (ECM) remodeling, cell adhesion, and cell signalling that controls cell migration by targeting a large number of protein-coding genes. Accordingly, the dysregulation of these miRNAs has been linked to several migration-related diseases. In this review, we summarize and highlight the recent advances concerning the roles and validated targets of miRNAs in the control of cell movement.
