Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control.
10.1007/s13238-014-0083-7
- Author:
Caiguo ZHANG
1
Author Information
1. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA, caiguo.zhang@ucdenver.edu.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Cycle Checkpoints;
DNA;
metabolism;
DNA Repair;
DNA Replication;
Hemeproteins;
genetics;
metabolism;
Iron;
chemistry;
metabolism;
Iron-Sulfur Proteins;
genetics;
metabolism;
Ribonucleotide Reductases;
genetics;
metabolism;
Yeasts;
metabolism
- From:
Protein & Cell
2014;5(10):750-760
- CountryChina
- Language:English
-
Abstract:
Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as a cofactor and perform key roles in DNA replication, DNA repair, metabolic catalysis, iron regulation and cell cycle progression. Disruption of iron homeostasis always impairs the functions of these iron-requiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals. Organisms have evolved multi-layered mechanisms to regulate iron balance to ensure genome stability and cell development. This review briefly provides current perspectives on iron homeostasis in yeast and mammals, and mainly summarizes the most recent understandings on iron-requiring protein functions involved in DNA stability maintenance and cell cycle control.
