Two Cases of Distal Renal Tubular Acidosis accompanied by Sjogren's Syndrome.
10.3904/kjm.2016.90.3.248
- Author:
Eunjeong KANG
1
;
Seokwoo PARK
;
Sehoon PARK
;
Hajeong LEE
;
Eun Young LEE
;
Jin Suk HAN
;
Kwon Wook JOO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. junephro@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Sjogren's syndrome;
Acidosis, Renal tubular;
Hypokalemia;
Nephrocalcinosis
- MeSH:
Acidosis;
Acidosis, Renal Tubular*;
Autoimmune Diseases;
Exocrine Glands;
Glomerular Filtration Rate;
Humans;
Hypokalemia;
Lower Extremity;
Nephrocalcinosis;
Salivary Glands;
Sjogren's Syndrome*;
Xerophthalmia;
Xerostomia
- From:Korean Journal of Medicine
2016;90(3):248-252
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inability to excrete highly acid urine, in which the impaired acid excretion is disproportional to the reduction in the glomerular filtration rate. Distal renal tubular acidosis (dRTA) is frequently associated with immune-mediated disease, including Sjogren's syndrome. Sjogren's syndrome is a systemic autoimmune disease that mainly affects exocrine glands, such as the lacrimal and salivary glands, resulting in xerophthalmia and xerostomia. Extraglandular manifestations are frequent and may include renal involvement. Recently, we experienced two cases of renal tubular acidosis in patients with Sjogren's syndrome. The first patient had lower extremity weakness and hypokalemia and the second had nephrocalcinosis. We discuss the frequency and pathogenesis of dRTA in Sjogren's syndrome.
