Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions.
10.1007/s13238-015-0136-6
- Author:
Yufei YANG
1
;
Mo HU
;
Kaiwen YU
;
Xiangmei ZENG
;
Xiaoyun LIU
Author Information
1. Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bacteria;
chemistry;
pathogenicity;
Bacterial Infections;
microbiology;
pathology;
Bacterial Proteins;
isolation & purification;
metabolism;
Host-Pathogen Interactions;
Humans;
Mass Spectrometry;
Protein Processing, Post-Translational;
Proteomics
- From:
Protein & Cell
2015;6(4):265-274
- CountryChina
- Language:English
-
Abstract:
Elucidation of molecular mechanisms underlying host-pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
