CRISPR/Cas9 and TALE: beyond cut and paste.
10.1007/s13238-015-0137-5
- Author:
Liping DENG
1
;
Ruotong REN
1
;
Jun WU
2
;
Keiichiro SUZUKI
2
;
Juan Carlos IZPISUA BELMOTE
2
;
Guang-Hui LIU
1
Author Information
1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
2. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA.
- Publication Type:Journal Article
- MeSH:
CRISPR-Cas Systems;
genetics;
Deoxyribonucleases;
genetics;
Gene Expression Regulation;
Genetic Engineering;
Genomics;
methods;
Humans;
RNA Editing;
genetics
- From:
Protein & Cell
2015;6(3):157-159
- CountryChina
- Language:English
-
Abstract:
Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.
