Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.
10.1007/s13238-015-0140-x
- Author:
Haisheng YU
1
;
Peng ZHANG
2
;
Xiangyun YIN
1
;
Zhao YIN
3
;
Quanxing SHI
3
;
Ya CUI
2
;
Guanyuan LIU
4
;
Shouli WANG
3
;
Pier Paolo PICCALUGA
5
;
Taijiao JIANG
2
;
Liguo ZHANG
1
Author Information
1. Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
2. Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
3. Department of Cardiology, 306th Hospital of PLA, Beijing, 100101 China.
4. Department of Gynecology and Obstetrics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020 China.
5. Department of Experimental, Diagnostic, and Specialty Medicine, Hematopathology & Hematology Sections, Molecular Pathology Laboratory, S. Orsola-Malpighi Hospital, Bologna University, Bologna, 40126 Italy.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
metabolism;
CD56 Antigen;
genetics;
immunology;
Cell Lineage;
genetics;
immunology;
Dendritic Cells;
immunology;
metabolism;
pathology;
Gene Expression;
Hematologic Neoplasms;
genetics;
immunology;
pathology;
Humans;
Immunophenotyping;
Interferon Type I;
biosynthesis;
metabolism;
Interleukin-12;
biosynthesis;
metabolism;
Interleukin-3 Receptor alpha Subunit;
genetics;
immunology;
Lectins, C-Type;
genetics;
immunology;
Membrane Glycoproteins;
genetics;
immunology;
Myeloid Cells;
immunology;
metabolism;
pathology;
Receptors, Immunologic;
genetics;
immunology;
Terminology as Topic;
Toll-Like Receptor 4;
genetics;
immunology;
Toll-Like Receptor 7;
genetics;
immunology;
Toll-Like Receptor 9;
genetics;
immunology
- From:
Protein & Cell
2015;6(4):297-306
- CountryChina
- Language:English
-
Abstract:
Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC population that express typical pDC markers including CD123 and BDCA2 but produce much less IFN-I comparing with pDCs. In addition, CD56(+) DCs cluster together with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, CD56(+) DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation and priming naïve T cells without prior activation. These data suggest that the CD56(+) DCs represent a novel mDC subset mixed with some pDC features. A CD4(+)CD56(+) hematological malignancy was classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its expression of characteristic molecules of pDCs. However, we demonstrated that BPDCN is closer to CD56(+) DCs than pDCs by global gene-expression profiling. Thus, we propose that the CD4(+)CD56(+) neoplasm may be a tumor counterpart of CD56(+) mDCs but not pDCs.
