Theoretical and simulation studies on voltage-gated sodium channels.
10.1007/s13238-015-0152-6
- Author:
Yang LI
1
;
Haipeng GONG
Author Information
1. MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
- Publication Type:Journal Article
- MeSH:
Ion Channel Gating;
Ligands;
Models, Biological;
Permeability;
Substrate Specificity;
Voltage-Gated Sodium Channels;
chemistry;
metabolism
- From:
Protein & Cell
2015;6(6):413-422
- CountryChina
- Language:English
-
Abstract:
Voltage-gated sodium (Nav) channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Nav channels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the progress in computational studies, especially the simulation studies, on these proteins in the past years.
