DNA methylome: Unveiling your biological age.
10.1007/s13238-013-3913-0
- Author:
Ming LI
1
;
Wensu LIU
;
Tingting YUAN
;
Ruijun BAI
;
Guang-Hui LIU
;
Weizhou ZHANG
;
Jing QU
Author Information
1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
- Publication Type:Journal Article
- MeSH:
Aging;
genetics;
pathology;
Base Sequence;
Chromatin;
genetics;
DNA Methylation;
genetics;
Epigenesis, Genetic;
Genome, Human;
Humans;
RNA, Untranslated;
genetics;
Sequence Analysis, DNA;
trends
- From:
Protein & Cell
2013;4(10):723-725
- CountryChina
- Language:English
-
Abstract:
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
