Mutual regulation between Hippo signaling and actin cytoskeleton.
10.1007/s13238-013-3084-z
- Author:
Yurika MATSUI
1
;
Zhi-Chun LAI
Author Information
1. Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
- Publication Type:Journal Article
- MeSH:
Actin Cytoskeleton;
physiology;
Adaptor Proteins, Signal Transducing;
genetics;
metabolism;
Animals;
Cell Proliferation;
Drosophila Proteins;
genetics;
metabolism;
Gene Expression Regulation;
Humans;
Intracellular Signaling Peptides and Proteins;
genetics;
metabolism;
Nuclear Proteins;
genetics;
metabolism;
Phosphoproteins;
genetics;
metabolism;
Phosphorylation;
Protein-Serine-Threonine Kinases;
genetics;
metabolism;
Signal Transduction;
Trans-Activators;
genetics;
metabolism;
Transcription Factors;
genetics;
metabolism
- From:
Protein & Cell
2013;4(12):904-910
- CountryChina
- Language:English
-
Abstract:
Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.
