Transitions between epithelial and mesenchymal states during cell fate conversions.
10.1007/s13238-014-0064-x
- Author:
Xiang LI
1
;
Duanqing PEI
;
Hui ZHENG
Author Information
1. CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Differentiation;
Cell Lineage;
Cellular Reprogramming;
Epigenesis, Genetic;
genetics;
Epithelial-Mesenchymal Transition;
Humans;
Induced Pluripotent Stem Cells;
cytology
- From:
Protein & Cell
2014;5(8):580-591
- CountryChina
- Language:English
-
Abstract:
Cell fate conversion is considered as the changing of one type of cells to another type including somatic cell reprogramming (de-differentiation), differentiation, and trans-differentiation. Epithelial and mesenchymal cells are two major types of cells and the transitions between these two cell states as epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been observed during multiple cell fate conversions including embryonic development, tumor progression and somatic cell reprogramming. In addition, MET and sequential EMT-MET during the generation of induced pluripotent stem cells (iPSC) from fibroblasts have been reported recently. Such observation is consistent with multiple rounds of sequential EMT-MET during embryonic development which could be considered as a reversed process of reprogramming at least partially. Therefore in current review, we briefly discussed the potential roles played by EMT, MET, or even sequential EMT-MET during different kinds of cell fate conversions. We also provided some preliminary hypotheses on the mechanisms that connect cell state transitions and cell fate conversions based on results collected from cell cycle, epigenetic regulation, and stemness acquisition.
