The substrates of Plk1, beyond the functions in mitosis.
10.1007/s13238-010-0131-x
- Author:
X Shawn LIU
1
;
Bing SONG
;
Xiaoqi LIU
Author Information
1. Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Cycle;
Cell Cycle Proteins;
chemistry;
metabolism;
Chromosomes;
metabolism;
DNA Replication;
Humans;
Microtubules;
metabolism;
Mitosis;
Protein-Serine-Threonine Kinases;
chemistry;
metabolism;
Proto-Oncogene Proteins;
chemistry;
metabolism;
Tumor Suppressor Protein p53;
metabolism
- From:
Protein & Cell
2010;1(11):999-1010
- CountryChina
- Language:English
-
Abstract:
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.
