RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities.
10.1007/s13238-010-0083-1
- Author:
Songling ZHANG
1
;
Wei WU
;
Yanfang WU
;
Jiyan ZHENG
;
Talin SUO
;
Hong TANG
;
Jie TANG
Author Information
1. Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, the Institute of Biophysics, Beijing, 100101, China.
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
Apoptosis;
HeLa Cells;
Humans;
Lysosomes;
metabolism;
Molecular Sequence Data;
Phylogeny;
Proteasome Endopeptidase Complex;
metabolism;
RING Finger Domains;
Sequence Alignment;
Ubiquitin-Protein Ligases;
metabolism;
Ubiquitination
- From:
Protein & Cell
2010;1(7):656-663
- CountryChina
- Language:English
-
Abstract:
RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.
