Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.

Yuan-qin Yang; Wen-jie Dong; Xiao-fei Yin; Yan-ni XU; Yu Yang; Jiao-jiao Wang; Su-jing Yuan; Jing Xiao; Jonathan Howard Delong; Liang Chu; Hai-neng XU; Xiu-mei Zhou; Ru-wei Wang; Ling Fang; Xin-yuan Liu; Kang-jian Zhang

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Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.

Author: Yuan-Qin YANG ¹ ; Wen-Jie DONG ¹ ; Xiao-Fei YIN ² ; Yan-Ni XU ³ ; Yu YANG ⁴ ; Jiao-Jiao WANG ¹ ; Su-Jing YUAN ² ; Jing XIAO ² ; Jonathan Howard DELONG ⁵ ; Liang CHU ² ; Hai-Neng XU ⁶ ; Xiu-Mei ZHOU ¹ ; Ru-Wei WANG ⁷ ; Ling FANG ⁷ ; Xin-Yuan LIU ⁸ ; Kang-Jian ZHANG ⁹
Author Information

1. Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
2. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
3. College of Life Sciences, Northwest Agriculture and Forestry University, Yangling, 712100, China.
4. Central China Normal University, Wuhan, 430079, China.
5. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
6. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
7. Zhejiang Conba Pharmaceutical Co., Ltd, Hangzhou, 310018, China.
8. Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University, Hangzhou, 310018, China. xyliu@sibcb.ac.cn.
9. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zhangkangjian@sibcb.ac.cn.
Publication Type:Letter
MeSH: Animals; B7-H1 Antigen; immunology; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; immunology; Humans; Interferons; immunology; Mice; Neoplasm Proteins; immunology; Neoplasms; immunology; Up-Regulation; immunology
From: Protein & Cell 2016;7(7):538-543
CountryChina
Language:English