DNA sensor cGAS-mediated immune recognition.
10.1007/s13238-016-0320-3
- Author:
Pengyan XIA
1
;
Shuo WANG
1
;
Pu GAO
1
;
Guangxia GAO
1
;
Zusen FAN
2
Author Information
1. Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
2. Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. fanz@moon.ibp.ac.cn.
- Publication Type:Journal Article
- Keywords:
DNA sensors;
cGAMP;
cGAS;
cytosolic DNAs;
innate immunity
- MeSH:
DNA, Bacterial;
immunology;
metabolism;
DNA, Viral;
immunology;
metabolism;
Gene Expression Regulation;
Host-Pathogen Interactions;
Humans;
Immunity, Innate;
Interferon Regulatory Factor-3;
genetics;
immunology;
Interferon Type I;
biosynthesis;
immunology;
Membrane Proteins;
genetics;
immunology;
Models, Molecular;
NF-kappa B;
genetics;
immunology;
Nucleotides, Cyclic;
biosynthesis;
immunology;
Nucleotidyltransferases;
genetics;
immunology;
Protein Binding;
Protein-Serine-Threonine Kinases;
genetics;
immunology;
Signal Transduction
- From:
Protein & Cell
2016;7(11):777-791
- CountryChina
- Language:English
-
Abstract:
The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.
