Comparative Bioavailability and Efficasy of Tobra(R) or Tobrex(R).
- Author:
Eung Kweon KIM
1
;
Hong Bok KIM
;
Sahng Yeon KIM
Author Information
1. Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tobra(R);
Tobrex(R);
bioavailability;
efficasy
- MeSH:
Biological Availability*;
Cornea;
Hydrogen-Ion Concentration;
Ophthalmic Solutions;
Pharmacokinetics;
Rabbits;
Tobramycin;
Ulcer;
Wound Healing
- From:Journal of the Korean Ophthalmological Society
1989;30(2):175-180
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Two topical 0.3% tobramycin ophthalmic solutions, Tobra(R) and Tobrex(R) were tested for their effects on external eyes in rabbits. The authors studied irritation, epithelial toxicity, pH of solutions and antibiotic pharmacokinetics of two kinds of topical tobramycin solutions. No irritation sings were noted after instillation of the two agents with one hour interval. A rabbit epithelial wound healing model demonstrated slight toxicity, but no substantial difference was noted between Tobra(R) and Tobrex(R). In the case of normal corneal epithelia, more than 1 microgram of tobramycin was detectable per gram of cornea 5 minutes after cessation of topical application with both eye drops. In the case of ulcers, the concentrations of tobramycin in the corneae were significantly high with topical route with both eye drops.
